Initial therapy: . / In infusion at a dose of 5 mg / kg over 1 hour every 12 hours for 7-14 days (patients with normal renal function)Maintenance therapy: by 5 mg / kg by intravenous primobolan side effects infusion over 1 hour, every day for 7 days per week or 6 mg / kg body weight daily for 5 days per week.
Because patients with renal insufficiency, the dose of ganciclovir should be adjusted, should be carefully monitored concentrations of serum creatinine or creatinine clearance.
Patients with leukopenia, severe neutropenia, anemia and thrombocytopenia. In patients receiving ganciclovir, observed cases of severe leukopenia, neutropenia, anemia, thrombocytopenia and myelosuppression, and aplastic anemia.
Do not start treatment with an absolute neutrophil count less than 500 cells in 1 mm, or platelet – less than 25,000 cells in 1 mm, or hemoglobin level below 8 g / dL .
Sick elderly: as in the elderly renal function is often decreased, ganciclovir should be given to them strictly in view of renal function (see above.).
Children: ganciclovir efficacy and safety in children under 12 years of age, including congenital and neonatal primobolan side effects infection have not been established. Due to the remote likelihood of carcinogenic and toxic effects on the reproductive system, the benefits of treatment should outweigh the possible risk.
The method of preparation of Cymevene solution
- The lyophilized powder was dissolved ganciclovir, introducing into the bottle 10 ml of sterile water for injection. Do not use bacteriostatic water for injection containing parabens (parahydroxybenzoates), because they are incompatible with the sterile powder of ganciclovir and may cause precipitation.
- Shake the vial to dissolve the drug.
- Inspect the prepared solution for the presence of impurities.
- The mixed solution in the vial is stable at room temperature for 12 hours.To put it in the refrigerator should not be.How to handle drug
case of contact with the primobolan side effects drug should be careful.
Since ganciclovir is considered a potential carcinogen and mutagen for human, care must be taken when handling them. It is necessary to avoid inhalation or direct contact of the powder contained in the vials or direct contact of the solution with the skin and mucous membranes. Cymevene solution is alkaline . After contact with ganciclovir on the skin or mucous membranes, this place should be rinsed thoroughly with soap and water. When eye contact with them just washed thoroughly with water.Preparation and administration of the infusion solution
from the vial with ganciclovir Calculate gain primobolan side effects dose of the drug is added to the base and the infusion solution . Administered ganciclovir in greater than 10 mg / ml is not recommended.
Ganciclovir can not be mixed with other intravenous drugs.
Since ganciclovir diluted nebakteriostaticheskoy sterile water, the infusion solution to reduce the bacterial contamination risks must be used within 24 hours after preparation.
The infusion solution should be stored in refrigerator ; freezing is not recommended.
The drug should not be administered intravenously or fast jet! Excess ganciclovir plasma concentration may increase its toxicity. Intramuscular or subcutaneous injection may cause severe tissue irritation due to the high of ganciclovir solution.
Do not exceed the recommended dose, and change the mode of administration or the rate of infusion.