With the simultaneous use of ganciclovir and imipenem + cilastatin may cause generalized sudorgi
Pharmaceutical incompatible with salts of lactic acid, and other antibacterial drugs. While the use of penicillins and cephalosporins can cross allergic reactions; exhibits antagonism to other beta-lactam antibiotics (penicillins, cephalosporins and monobactams). Drugs primo steroid that block tubular secretion, and slightly increase the concentration in plasma and T ½ imipenem (if required high concentration of imipenem, to use these drugs at the same time is not recommended).
Significantly vaplproevoy it reduces the concentration of acid in the blood, which can reduce the effectiveness of the anticonvulsant.
It is not recommended for treatment of meningitis. Urine stains in reddish color.
The therapy with antiepileptic drugs in patients with brain injury or seizures in history must continue throughout the period of treatment (in order to avoid adverse effects on the central nervous system).
Before initiating therapy careful history should be collected for the previous allergic reactions to beta-lactam antibiotics.
in persons with a history of gastrointestinal disease (especially colitis), there is an increased risk of pseudomembranous colitis. It should be borne in mind that in elderly patients likely to have age-related renal dysfunction, which may require dose reduction.
The dosage form for intravenous use primo steroid should not be administered intramuscularly.
The appointment of imipenem + cilastatin patients undergoing hemodialysis is recommended only in cases where the benefits from the treatment outweighs the potential risk of seizures.
Effects on ability to drive and operate machinery
Given the likelihood of adverse effects on the central nervous system should be careful when driving and working with machinery.
Powder for solution for infusion is 500 mg + 500 mg.
500 mg + 500 mg (calculated as imipenem primo steroid and cilastatin, respectively) in a bottle made of transparent colorless glass capacity of 20 ml, a sealed with a rubber stopper and crimped aluminum cap with plastic protective cover. 1 bottle with instruction on use are placed in a stack of cardboard.